Urolithin A (XJY-UA 97%)
CAS# 1143-70-0
Urolithin A is produced by gut flora and is a natural metabolite of ellagitannins, a class of compounds (polyphenolic antioxidant) found in pomegranates and some other fruits and nuts.
Quantity
Urolithin Ais a natural metabolite produced by gut bacteria breaking down polyphenols (ellagic acid and ellagitannins) in our food but only some bacteria are able to convert them into urolithins. It is used as dietary supplements and new drug development.
Product Detail
| Product name | Urolithin A |
| Synonyms | Uro-A; UA |
| CAS number | 1143-70-0 |
| Molecular Formula | C13H8O4 |
| Molecular weight | 228.20 |
| Appearance/color | Light yellow powder |
| Specifications | >97% (HPLC) |
| Stability | Sealed package, stored at cool, dry and away from light |
| Shelf life | 24 months |
How it works?
Urolithin A improves mitochondrial function by stimulating a process called mitophagy.
Mitophagy, the targeted autophagy and destruction of mitochondria by the cell's autophagic apparatus, is generally considered to be the main mechanism of mitochondrial quality control. This is an evolutionarily conserved cellular process to clear dysfunctional or redundant mitochondria, thereby fine-tuning mitochondrial number and maintaining energy metabolism.
Mitophagy, the targeted autophagy and destruction of mitochondria by the cell's autophagic apparatus, is generally considered to be the main mechanism of mitochondrial quality control. This is an evolutionarily conserved cellular process to clear dysfunctional or redundant mitochondria, thereby fine-tuning mitochondrial number and maintaining energy metabolism.
Schematic Representation of Mitophagy Pathways Activated by Urolithin A (UA):
pink arrow>>>> activates PINK1–Parkin-mediated mitophagy by stabilizing the kinase PINK1.
blue arrow>>>> activates a PINK1–Parkin-independent pathway by increasing mitochondrial BNIP3 levels.
pink arrow>>>> activates PINK1–Parkin-mediated mitophagy by stabilizing the kinase PINK1.
blue arrow>>>> activates a PINK1–Parkin-independent pathway by increasing mitochondrial BNIP3 levels.
Davide D' Amico, Pénélope A. Andreux, Pamela Valdés, Anurag Singh,Chris Rinsch, and Johan Auwerx.(2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends Mol Med. 2021 Jul;27(7):687-699. DOI:https://doi.org/10.1016/j.molmed.2021.04.009
| IMPORTANT: This infomation is not intended to diagnose, treat, cure, or prevent any disease, and it should not be used by anyone who is pregnant or under the care of a medical practitioner. Please consult your physician about which supplements may or may not be right for you. |
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