Health & Anti Ageing: Fisetin– A Powerful Natural Flavonoid

 

The Source of Fisetin is mainly from plant extracts:

• Cotinus coggygria;
• Plants such as the wax tree,Rhus vernciflua Stokes;
• Fruits and vegetables, such as apples, persimmons, grapes, kiwis, strawberries, onions and cucumbers and ect.

• Flavonols: onions, grapes, broccoli, tea
• Flavones: celery, red peppers, peppermint,chamomile
• Flavan-3-ols: apples, blueberries, strawberries, cocoa and chocolate products
• Flavanones: limes, lemons, oranges
• Anthocyanidins: red and purple grapes, blackberries, cranberries
• Isoflavones: soy, soy products, and some other legumes

Mechanism

In 1966, an article published in “Nature” stated that fisetin was one of the flavonoids with the strongest antibacterial effect known at that time, requiring only 50 μg/ml to effectively inhibit the growth of bacteria such as Staphylococcus aureus,which drew the attention of scientists to the pharmacological effects of fisetin. In subsequent studies on fisetin, scientists discovered that it has antioxidant and anti-inflammatory effects.

As a flavonoid, fisetin has natural antioxidant properties. It not only has direct antioxidant activity, but also increases the level of the main antioxidant glutathione in cells. Even in the case of oxidative stress, fisetin can maintain mitochondrial function well, and even very fragile neuron cells can be well protected.

In addition to its own antioxidant talent, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, which in turn down-regulates the release of inflammatory cytokines and achieves anti-inflammatory effects.

 

Application of Fisetin:

 

Antioxidants

Studies have shown that fisetin has the ability to scavenge free radicals with significant biological effects. These oxygen radicals damage lipids, amino acids, carbohydrates and nucleic acids. When we do not consume enough antioxidant foods, an imbalance of oxygen species occurs, which inhibits the body’s ability to defend itself.

 

Anti-aging Activity

Research published in ‘The Lancet’ shows that fisetin, a flavonoid, has potent anti-aging activity in both mice and human tissues. This means that antioxidants could prevent the replication of damaged DNA and thus may play a role in aging and age-related diseases.

When researchers tested 10 flavonoids(including resveratrol, rutin, luteolin, curcumin, and fisetin),they found that fisetin was the most effective anti-aging material.

 

Reduce Inflammation

According to research published in Advances in Experimental Medicine and Biology, fisetin has been shown to have potent anti-inflammatory effects in cell cultures and in animal models associated with human disease.